| 1/1/1921, Sat | New Year's Day |
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| 1/10/1921, Mon | Epiphany Obs: Actual Observance Day |
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| 3/20/1921, Sun | Palm Sunday |
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| 3/21/1921, Mon | St. Joseph's Day Obs: Actual Observance Day |
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| 3/24/1921, Thu | Maundy Thursday |
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| 3/25/1921, Fri | Good Friday |
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| 3/26/1921, Sat | Holy Saturday |
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| 3/27/1921, Sun | Easter |
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| 5/1/1921, Sun | Labor Day |
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| 5/9/1921, Mon | Ascension Obs: Actual Observance Day |
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| 5/30/1921, Mon | Corpus Christi Obs: Actual Observance Day |
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| 6/6/1921, Mon | Sacred Heart Obs |
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| 7/4/1921, Mon | St. Peter-St. Paul Day Obs: Actual Observance Day |
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| 7/20/1921, Wed | Independence Day |
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| 8/7/1921, Sun | Battle of Boyaca |
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| 8/15/1921, Mon | Assumption Obs |
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| 10/17/1921, Mon | Hispanity Day Obs: Actual Observance Day |
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| 11/7/1921, Mon | All Saints' Day Obs: Actual Observance Day |
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| 12/8/1921, Thu | Immaculate Conception |
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| 12/24/1921, Sat | Christmas Eve |
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| 12/25/1921, Sun | Christmas Day |
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| 12/31/1921, Sat | New Year's Eve |
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